How To Use Isomerase In A Sentence
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Similarly, in ketosteroid isomerase, Asp99 may catalyze proton transfers in the Asp38Ala variant [
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Therefore a ring opening step will be the first step catalyzed by isomerases for any pentose or hexose substrate.
Irwin Rose - Autobiography
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Further, the broken site at the TT4 gene contained a potential topoisomerase I cleavage site.
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The region includes genes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-dependent dehydrogenase (ORF13), and a bifunctional isomerase/hydrolase (dntG).
Casey Luskin on Kitzmiller & Information
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As shown in Table 1, isomerases that are specific for 2R-aldoses were found to activate the 1-R proton of the ketose produced.
Irwin Rose - Autobiography
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A heart-shaped molecular donut, the topoisomerase II dimer boasts an electropositive tunnel, the likely passage point for DNA.
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The anomeric specificities of 5 isomerases were determined in the course of our studies on the isomerases that continued until 1973.
Irwin Rose - Autobiography
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Topoisomerase III is a type I topoisomerase, acting on DNA that is negatively supercoiled and/or contains single-strand regions.
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The enzyme catalyzing this reaction is phosphohexose isomerase (also known as phosphoglucose isomerase).
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We had been mistakenly unsuccessful in not finding the small amount of transfer that was later detected in the triose P isomerase reaction.
Irwin Rose - Autobiography
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It was shown also that the same critical concentration of spermidine induces aggregation and catenation of DNA rings by topoisomerases.
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It had been observed by Harland Wood's group at Western Reserve that when 14C-lactate or 14C-glycerol are fed to a fasted animal the labeling of the glucose units of liver glycogen was such as to suggest that triose-P isomerase had failed to equilibrate its two triose phosphate substrates during synthesis, or that the condensation reaction of FDP aldolase did not give equal labeling of the two halves of
Irwin Rose - Autobiography
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This study illuminates some of the similarities and differences in the topoisomerase / DNA complex in eukaryotes and prokaryotes.
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Ordinary corn syrup is treated with the enzyme glucose isomerase which converts glucose to fructose.
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Both topoisomerase I and RNA polymerase II reactivity occurs in the minor groove of DNA.
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The mutation results in loss of RAD51 focus formation in response to DNA damage and in increased cellular sensitivity to the DNA interstrand cross-linking agent mitomycin C and the topoisomerase-1 inhibitor camptothecin.
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The value for the ancestor was expressed relative to the midpoint topoisomer of plasmid that was completely relaxed by using calf-thymus topoisomerase I and assigned = 0.
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A heart-shaped molecular donut, the topoisomerase II dimer boasts an electropositive tunnel, the likely passage point for DNA.
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When G6P was used with isomerase in D2O the colorimetric analysis for fructose-6-P passed through a maximum before reaching a final value.
Irwin Rose - Autobiography
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This domain, which is not found in eukaryotic topoisomerases, might be involved in the bending and right-handed wrapping of DNA observed for both Gyrase and Topo IV.
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In nature, the function is performed by the enzyme triose phosphate isomerase.
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These DNA-binding proteins include polymerases, helicases, nucleases, isomerases, ligases, histones, and others.
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The evolution of protein disulfide isomerases presents a difficult but important phylogenetic question.
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In unrelated experiments I observed a puzzling phenomenon with G6P isomerase.
Irwin Rose - Autobiography
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It reduced levels of glycolytic enzymes such as hexokinase, phosphoglucoisomerase and aldolase levels, which are increased in hepatoma-bearing rats, and increased levels of gluconeogenic enzymes such as glucose. 6-phosphatase and fructose-I
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When G6P was used with isomerase in D2O the colorimetric analysis for fructose-6-P passed through a maximum before reaching a final value.
Irwin Rose - Autobiography
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The product is manipulated, using a process that includes alpha-amylase, oligosaccharides, and xylose isomerase, into a syrup that is anywhere from 90% fructose/10% glucose to 42% fructose/58% glucose.
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It had been observed by Harland Wood's group at Western Reserve that when 14C-lactate or 14C-glycerol are fed to a fasted animal the labeling of the glucose units of liver glycogen was such as to suggest that triose-P isomerase had failed to equilibrate its two triose phosphate substrates during synthesis, or that the condensation reaction of FDP aldolase did not give equal labeling of the two halves of
Irwin Rose - Autobiography
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Although there are several ER-localized HSPs that can potentially chaperone PRRs, including calnexin, calreticulin, protein disulfide isomerase, gp96, thiol-oxidoreductase ERp57, and BiP, to date only gp96 has been demonstrated to function in PRR-folding
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An in vitro study showed that the collision between a moving replication fork and a stalled topoisomerase can convert the complex to a nonreversible form.
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Aconitate isomerase catalyzes the interconversion of cis - and trans-aconitate by a 1, 3 allylic rearrangement that uses the (pro-S) hydrogens of the two substrates.
Irwin Rose - Autobiography
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The region includes genes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-dependent dehydrogenase (ORF13), and a bifunctional isomerase/hydrolase (dntG).
Casey Luskin on Kitzmiller & Information
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As to segregation of replicated daughter molecules, to be discussed later, topoisomerase II is thought to locate DNA crossovers such as those present in catenated molecules.
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Taken together, these results indicate that the overexpression of the topoisomerase I gene causes DNA damage that is lethal only in the scaA - background.
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The enzyme catalyzing this reaction is phosphohexose isomerase (also known as phosphoglucose isomerase).
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Other categories include transferases, oxidoreductases, ligases, lyases, isomerases, proteases, molecular chaperons, and GTPases.
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Among the genes affected by supercoiling are the topoisomerase genes.
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Down-regulated topoisomerase II gene expression in etoposide-selected cells has also been shown to be associated with an increased rate of spontaneous polyploidization.
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The region includes genes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-dependent dehydrogenase (ORF13), and a bifunctional isomerase/hydrolase (dntG).
Casey Luskin on Kitzmiller & Information
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DNA topoisomerase I may play a major role in transcription; the enzyme is physically associated with actively transcribed regions of chromatin where it reduces torsional stress generated during transcription.
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These DNA-binding proteins include polymerases, helicases, nucleases, isomerases, ligases, histones, and others.
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In nature, the function is performed by the enzyme triose phosphate isomerase.
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Phosphoglucose isomerase is a protein with multiple functions.
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< 1, 3 > [2, 3] S Additional information (molecular mechanism of intracellular degradation of type I collagen in normal corneal endothelial cells, role of the enzyme and protein-disulfide isomerase, which is the b subunit of the enzyme, during procollagen I biosynthesis [72]) [72] P?
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The region includes genes encoding a CoA-dependent methylmalonate semialdehyde dehydrogenase (dntE), a putative NADH-dependent dehydrogenase (ORF13), and a bifunctional isomerase/hydrolase (dntG).
Casey Luskin on Kitzmiller & Information
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The newly identified isomerase enzyme plays a crucial role in the regeneration of rhodopsin visual pigment in the retina after light exposure.
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The physical separation of H - from D-labeled molecules made possible by their different rates of reaction was used to establish that the transfer of hydrogen in G6P isomerase was intramolecular9 and that the site of attachment of CO2 to ribulose-1, 5-P2 to produce two molecules of phosphoglyceric acid had to be to C-2 rather than C-4 in the RUDP carboxylase reaction47.
Irwin Rose - Autobiography
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H1-responses to Asp f3 (a putative peroxismal membrane protein), Asp f9/16 (cell wall glucanase), Asp f11 (cyclophilin type peptidyl-prolyl isomerase) and Asp f22 (enolase).
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The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle.
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Since topoisomerase activity is needed for replication, inhibition of topoisomerases might prevent replication in irradiated S phase cells, avoiding DNA synthesis upon a damaged template.
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These compounds stabilize and trap the topoisomerase I - DNA complex, preventing the religation step of the breakage/rejoining reaction mediated by the enzyme.
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Asymmetric labeling due to incomplete equilibration at the triose-P isomerase step seemed unlikely given the enzyme's high efficiency.
Irwin Rose - Autobiography
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AQ4 is a potent topoisomerase II inhibitor and DNA intercalator.
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We had been mistakenly unsuccessful in not finding the small amount of transfer that was later detected in the triose P isomerase reaction.
Irwin Rose - Autobiography
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What, on earth, compelled anyone to use xylose isomerase and oligosaccharides in the first place?
Sophie Brickman: Why Is It Easier To Buy A Gun Than High-Fructose Corn Syrup?
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Recent studies in Xenopus have shown a role for DNA replication in the recruitment of topoisomerase II to the chromosomes to facilitate condensin assembly and condensation.
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Irinotecan is a camptothecin analogue that acts through the inhibition of a DNA unwinding enzyme, topoisomerase I, resulting in replication arrest with breaks in single strand DNA.
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The physical separation of H - from D-labeled molecules made possible by their different rates of reaction was used to establish that the transfer of hydrogen in G6P isomerase was intramolecular9 and that the site of attachment of CO2 to ribulose-1, 5-P2 to produce two molecules of phosphoglyceric acid had to be to C-2 rather than C-4 in the RUDP carboxylase reaction47.
Irwin Rose - Autobiography
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Sequence analysis showed that enolase had 74.8% similarity with that of Fascioliasis at amino acid level and belonged to phosphate-binding triosephosphate isomerase protein family.
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Sucrose isomerase catalyses the reversible conversion of sucrose into palatinose, which is not further metabolizable by plant cells.
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Finally, the in vivo catalytic activities of eukarytotic type IA topoisomerases, the topoisomerase III from various higher organisms may be related to their sequences.
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Aconitate isomerase catalyzes the interconversion of cis - and trans-aconitate by a 1, 3 allylic rearrangement that uses the (pro-S) hydrogens of the two substrates.
Irwin Rose - Autobiography
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A relation between the cis-enediol mechanism and the anomeric specificity of isomerases.
Irwin Rose - Autobiography
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The specificity of glucose-6-P isomerase is unusual.
Irwin Rose - Autobiography
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DNA topoisomerase II is an essential cellular enzyme that functions in the segregation of chromosome pairs and in chromosome condensation.
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In certain cases, the combination of a helicase and a topoisomerase provides a unique biological function and the interaction between the two is evolutionarily conserved.
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Aconitate isomerase catalyzes the interconversion of cis - and trans-aconitate by a 1, 3 allylic rearrangement that uses the (pro-S) hydrogens of the two substrates.
Irwin Rose - Autobiography
