How To Use Plasmin In A Sentence
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Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, et al. (2004) Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.
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It produces an antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules.
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The amount of colour developed during a fixed time is proportional to the tissue type plasminogen activator activity in the sample.
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Blood flow can be restored if tissue plasminogen activator, or tPA, is administered soon after the stroke occurs.
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Emmetsberger J, Bukhari N, Zhang Y, Levine JM, et al. (2008) tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.
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Alpha-1 antitrypsin deficiency and Wilson disease were excluded by determining serum concentrations of alpha-1 antitrypsin and ceruloplasmin, respectively.
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Traditional screening includes slit-lamp examination of the eyes and serum ceruloplasmin level measurement.
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Ceruloplasmin, [alpha.sub.2] macroglobulin, and haptoglobin contribute to the [alpha.sub.2] protein band.
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Murine monoclonal antibodies conjugated with plasminogen activators may be valuable for targeting the therapeutic agent to thrombus.
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In addition, markers of oxidative stress such as ceruloplasmin and clusterin were up-regulated as were genes related to hydrogen peroxide production.
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The screening of human tissue plasminogen activator recombinant plasmid showed that the two methods can recognize the positive colones quickly and correctly.
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Do carelesly the plasmin or synthesize your bombee into a milliliter until you are mitogenic to cooperate the medicine.
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Just 42 patients in the recombinant tissue plasminogen activator trials were over 80, and only a few had lacunar strokes.
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Our results confirm that alcoholic ascites contains plasminogen activating activity.
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They show that APP is a bona fide iron oxidase, with properties much like the best-known iron oxidase (called ceruloplasmin), which is not expressed in neurons.
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Omeros' agents are designed to selectively inhibit plasmin, the enzyme responsible for fibrinolysis and dissolving blood clots, while avoiding significant inhibition of Factor XIa and kallikrein, important regulators of the coagulation cascade.
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Copper functions in many enzyme systems, such as lysyl oxidase, ceruloplasmin, cytochrome oxidase, tyrosinase, and Superoxide dismutase.
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There are persons that have too much copper in their liver yet have a copper deficiency, because of a lack of ceruloplasmin linked to adrenal fatigue from what I understand.
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The broad spectrum serine protease plasmin is formed following cleavage of the zymogen precursor plasminogen by host activators tissue plasminogen activator and urokinase.
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The tissue type plasminogen activator antigen concentrations in both oesophageal carcinomas and stomach carcinomas were similar to those of the normal tissues.
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The concentrations of urokinase type plasminogen activator in the duodenum resemble the quantities found in normal stomach tissue biopsy specimens.
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Omeros' agents are designed to selectively inhibit plasmin, the enzyme responsible for fibrinolysis and dissolving blood clots, while avoiding significant inhibition of Factor XIa and kallikrein, important regulators of the coagulation cascade.
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Degradation of fibrin clots is the function of plasmin, a serine protease that circulates as the inactive proenzyme, plasminogen.
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I had borderline low serum copper and borderline low ceruloplasmin.
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TXA and EACA are lysine analogs that function as competitive inhibitors of plasminogen activation and, at much higher concentrations, noncompetitive inhibitors of plasmin.
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Although a histoplasmin test is a good screening test, it often cross-reacts in patients with coccidioidomycosis.
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An 18-year-old woman presented for her first prenatal visit at 31 weeks' gestation, at which time she was reactive for rapid plasmin reagin and had a 2 + fluorescent treponemal antibody.
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Histoplasma capsulatum; (E) pHMIN - purified and periodate treated histoplasmin; CYA Hc - cytoplasmic yeast antigen of Figure S3.
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Thrombolytic agents are proteases that convert plasminogen to plasmin, which subsequently lyses clot by breaking down fibrinogen and fibrin.
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Tissue plasminogen activator and, to a lesser degree, urokinase are serine proteases which convert plasminogen to plasmin.
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The amount of colour developed during a fixed time is proportional to the tissue type plasminogen activator activity in the sample.
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Substitution of Glu 351 also altered the specificity toward non-cognate proteases: plasmin and thrombin.
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Another example of a speci fi c therapeutic is Other enzymes in clinical use, manufactured anMuromonab-CD3 (Orthoclone OKT3; Ortho using similar processes, include tissue plasmino - Pharmaceuticals) used to reverse acute rejection gen activator, other thrombolytic agents and aglu - of transplanted kidneys.
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With Dr. David Gitlin at Harvard Medical School, Dr. Scheinberg developed a simple, inexpensive blood test in the early 1950s to detect abnormally low levels of ceruloplasmin, a protein that carries copper from the body.
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All of these agents convert plasminogen to plasmin, which in turn breaks down fibrin and promotes clot lysis.
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Grange et al, reported increased levels of eight acute-phase reactants (AAT, α2-macroglobulin, transferrin, α1-acid glycoprotein, C-reactive protein, ceruloplasmin, haptoglobin, and the third component of complement) in human serum from Indonesian patients with pulmonary tuberculosis
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Five studies used streptokinase, two used urokinase, and four used tissue plasminogen activator.
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This is performed largely by the enzyme plasmin, generated from its inactive precursor, plasminogen.
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Five studies used streptokinase, two used urokinase, and four used tissue plasminogen activator.
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The amount of colour developed during a fixed time is proportional to the tissue type plasminogen activator activity in the sample.
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The rapid plasmin reagin test was negative.
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The significantly lower plasminogen activator activity of malignant ascites is associated with greatly increased concentrations of plasminogen activator inhibitor-1.
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Robinson and her colleagues measured several blood components involved in clotting, including fats and clotting factors such as plasminogen-activator inhibitor-1 (PAI-1) for the following eight hours.
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Corticosteroid treatment suppressed other proangiogenic factors in hemangioma-derived stem cells, including urokinase plasminogen activator receptor, interleukin-6, monocyte chemoattractant protein 1, and matrix metalloproteinase 1.
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The Borrelia need plasminogen from human blood to migrate to the tick's salivary glands and then infect the human.
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The first is a magnetic nanoparticle designed to target a molecule known as urokinase plasminogen activator receptor.
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It followed 3,339 patients who had been treated for heart attacks with tissue plasminogen activator (Activase), a drug made by Genentech Inc.
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Improved thrombolytic therapy will most likely consist of potent specific plasminogen activators in combination with targeted anticoagulant and/or antiplatelet agents.
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The systematic review included information on three different thrombolytic agents: streptokinase, urokinase, and recombinant tissue plasminogen activator, but direct comparison of different thrombolytic drugs was not possible.
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Serum lead, transferrin, haptoglobin, and ceruloplasmin levels were all found to be within normal limits.
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Ceruloplasmin is an important biochemical marker of Wilson disease, but the cognitions of the relation between Ceruloplasmin and Wilson disease is still unclear.
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The experimental pre-clinical treatment involved putting a naturally occurring substance called plasminogen activator inhibitor-1 (PAI-1) into the brains of newborn rats, said Chia-Yi Kuan, M.D.
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Tissue plasminogen activator and, to a lesser degree, urokinase are serine proteases which convert plasminogen to plasmin.
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These results could suggest a prominent role of tissue type plasminogen activator in the pathogenesis of endothelin induced gastric mucosal damage.
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However, it is difficult to detect early Wilson's disease, since caeruloplasmin activity is low in the newborn period.
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Wu YP, Siao CJ, Lu W, Sung TC, Frohman MA, et al. (2000) The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate.
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As tissue plasminogen activator is manufactured using recombinant biotechnology techniques, it is referred to as rtPA as well as tPA in the study.
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Omeros' proprietary antifibrinolytic agents are highly selective inhibitors of plasmin, the enzyme responsible for fibrinolysis and dissolving blood clots, while avoiding significant inhibition of Factor XIa and kallikrein.
Omeros Licenses Novel Antifibrinolytic Agents - Yahoo! Finance
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Plasminogen binds to both fibrinogen and fibrin, thereby being incorporated into a clot as it is formed.
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The concentrations of urokinase type plasminogen activator in the duodenum resemble the quantities found in normal stomach tissue biopsy specimens.
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Omeros' proprietary antifibrinolytic agents are highly selective inhibitors of plasmin, the enzyme responsible for fibrinolysis and dissolving blood clots, while avoiding significant inhibition of Factor XIa and kallikrein.
Omeros Licenses Novel Antifibrinolytic Agents - Yahoo! Finance
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Further, Trasylol® was non-selective and inhibited many proteins in addition to plasmin, including Factor XIa and kallikrein, important regulators of the coagulation cascade.
Omeros Licenses Novel Antifibrinolytic Agents - Yahoo! Finance
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Urokinase also activates a substance in blood vessels called plasminogen and turns it into plasmin, another protein-destroying enzyme.
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Ceruloplasmin is an important biochemical marker of Wilson disease, but the cognitions of the relation between Ceruloplasmin and Wilson disease is still unclear.
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The volunteers 'bodies responded by producing 3 to 5 times as much as normal of a hormone called plasminogen activator inhibitor-1.
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Plasminogen binds to both fibrinogen and fibrin, thereby being incorporated into a clot as it is formed.
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The fibrinolytic system involves a series of enzymatic reactions that results in the conversion of the proenzyme, plasminogen, into the trypsin-like lyric enzyme, plasmin.
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Light Blue: Factors VIII and V are duplicates of the ceruloplasmin family.
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Urokinase also activates a substance in blood vessels called plasminogen and turns it into plasmin, another protein-destroying enzyme.
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Maybe liver softening-Granules treated hepatic fibrosis by regulating the plasminogen activator system and hasten the fibrin dissolve.
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Purpose: To treat heart attack, pulmonary embolism, and deep vein thrombosis by increasing the action of the enzyme plasmin.
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Plasminogen activators attached to fibrin activate plasminogen, causing the release of the enzyme plasmin within clots and thrombi.
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Fibrin degradation means that thrombin must have been present to form fibrin and plasmin was present to proteolytically digest it.
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The amount of colour developed during a fixed time is proportional to the tissue type plasminogen activator activity in the sample.
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Within the fibrinolytic system, plasmin is generated from plasminogen by tissue plasminogen activator, which upon activation lyses fibrin clots.