How To Use Preclinical In A Sentence
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In addition, Array has completed long-term preclinical regulated safety studies and has identified a commercially viable synthetic process and oral formulation for ARRY-162.
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These results, although striking, deserve additional investigation within preclinical models of allergic airway disease and possibly, subsequent investigation in populations of patients with asthma.
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Some recent reviews are listed here on general properties of porphyrins as sensitizers and on their preclinical and clinical tests.
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It covers 4300 journals devoted to medicine, nursing, dentistry, veterinary medicine, healthcare systems, and the preclinical sciences.
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The proportion of biomedical research paid for by industry has changed little during the past 10 years, but the pharmaceutical industry has shifted its focus away from preclinical research and towards clinical trials.
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These findings suggest a need for in vivo studies with this combination in preclinical prostate cancer models.
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Clinical process divides typical armour hepatitis a phase: is preclinical, prodrome period, is icteric period, convalescence.
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Only five compounds out of 5,000 in preclinical tests get as far as human trials.
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If patients aged over 45 with other risk factors are screened every three years, and those with impaired fasting glucose have an oral glucose tolerance test, nearly all cases of diabetes will be identified in a preclinical phase.
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A number of such vectors are currently being developed and tested in preclinical and early phase clinical trials.
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Modern medical science can be divided preclinical medicinemedicine, applied medicine and medical humanity.
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Mercury is neurotoxic, and even in people with low level chronic exposure, subtle preclinical effects on symptoms, mood, motor function, and cognition have been identified.
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Stoffers D, Booij J, van Eck-Smit BL, Wolters E, et al. (2004) Idiopathic hyposmia as a preclinical sign of Parkinson's disease.
PLoS ONE Alerts: New Articles
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Roche said Intermune's experimental medicine danoprevir "has shown promising efficacy in preclinical and early clinical development" and should "increase flexibility" to develop and market Roche's portfolio of drugs against hepatitis C, an infection of the liver that affects around 180 million people worldwide.
Business Watch
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They also do the vast majority of drug development, from preclinical animal studies through human clinical trials (the latter in collaboration with academic medical centers), and bear the economic risk.
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(Preclinical research with diabetic mice showed that mecamylamine had the ability to stop the process that contributed to the development and progression of diabetic macular edema.)
Medlogs - Recent stories
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Based on preclinical studies and clinical trials in other cancers, we believe that our technology has the potential to be a safe and effective treatment for this challenging disease.
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These are proving particularly effective for treating cancer in preclinical models.
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Elevating plasma cortisol levels, either by exogenous administration or stress, facilitates the acquisition of stimulant administration in preclinical rodent models.
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Another small preclinical study demonstrated improved tumor response for human rectal-carcinoma xenografts treated with PDT under hyperbaric oxygen.
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It is entirely possible that more such foods can be developed, but each will either be an outgrowth of traditional practices confirmed by usage, or will require the kind of preclinical and clinical testing described in PAG Guidelines 6, 7, and 12 (7 -
Chapter 28
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He said he hopes the model will be useful in preclinical testing of possible preventive therapies before they are given to human subjects.
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Preclinical data • levetiracetam is not active against acute seizures, namely the maximal electroshock (MES) and pentylenetetrazol (PTZ) seizure tests • Levetiracetam also appears to lack anticonvulsant activity in other acute seizure tests utilizing chemoconvulsant agents,
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Several drugs are currently under preclinical and early phase clinical study.
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The drugs are in clinical and preclinical trials.
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Beyond the fear and uncertainty about this illness, the diabetes study has been condemned for insufficient preclinical research.
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In preclinical and clinical studies at cytostatic doses, paclitaxel has demonstrated promising results for reducing the processes leading to restenosis.
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This provides a wide therapeutic window, especially as groups at risk are identified earlier and preclinical diagnosis becomes feasible.
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It has two main businesses: preclinical services, which assists companies with laboratory, toxicology and related resources; and research models and services, which supports companies in early-stage drug research.
Charles River Replaces Two Board Members
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Medical students with high preclinical and clinical grade point averages were, surprisingly, more likely to express an external orientation.
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In 2001 and 2002 we completed all of our clinical trials, our preclinical trials, and the animal work and bench work on the product.
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He trained at Edinburgh because Guy's would not recognise his preclinical year at Witswattersrand University.
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Researchers in the United States have identified two observable measures that predict future professionalism: conscientious behaviour; and humility in self assessment in the preclinical years.
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They also added a new research category called preclinical Alzheimer's, the earliest stage of the disease when clumps of amyloid start to form in the brains of people who are otherwise healthy.
Yahoo! News: Business - Opinion
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I was 20, a first year preclinical student, awaiting surgery for a large hiatus hernia.
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Just over a third are in preclinical, that is not a surprise, there are a lot of shots on goal.
SeekingAlpha.com: Home Page
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Had preclinical trials involved 50 rhesus monkeys instead of 20, and also involved chimpanzees as well as rats, mice and rabbits, then the potential for a catastrophic event in humans might have been detected.
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PA401 is a glycan-binding decoy protein based on human chemokine IL-8 (CXCL8), which has shown potent anti-inflammatory activity in both chronic and acute preclinical models of lung inflammation.
The Earth Times Online Newspaper
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Research and development is currently at preclinical stage, progressing to Phase I clinical trials in 2005.
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Alzheimer's disease is characterised by a long preclinical period during which cognitive deficits are detectable.
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After graduation, he decided to follow a growing conviction that his life should be in medicine, and he moved to Oxford for preclinical studies.
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‘What we're discovering about the human genome has implications in every stage from preclinical research to the point where you start putting new drugs into people,’ he says.
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Preclinical studies suggest that As 2 O 3 induces apoptosis and possibly differentiation in APL cells.
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The researchers noted that of the 86 preclinical dental students in Paris who did not have regular contact with latex gloves, all had negative skin test results when the same battery of skin tests was used.
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The authors called for greater use of systematic reviews in preclinical drug evaluation.
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By developing excellent preclinical safety profiles of drug candidates, it has been able to streamline development, allowing researchers to rapidly assess a drug's antiviral activity and effectiveness.
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In preclinical testing these vectors were highly effective against cancerous tumors and did not harm normal tissues.
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In addition, the Company has completed long-term preclinical regulated safety studies and has identified a commercially viable synthetic process and oral formulation for ARRY-162.
Health News from Medical News Today
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I had just finished my preclinical training at Cambridge and had come down to London to walk the wards at Bart's.
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Nevertheless, Chen et al. end their paper on a cautiously optimistic note:Although our preclinical mouse data showed that tumor growth was significantly decreased Fig. 2, the use of pharmacologic ascorbate as a single agent was not curative.
Archive 2008-08-01
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Well, Geller Pharmaceuticals conducted extensive preclinical rodent studies, did it not?
THE ASSOCIATE
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It's sufficient to say that preclinical medical students aren't the only people a little enamored with this disease.
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BioCryst Pharmaceuticals surged 44 cents, or 12%, to 4.11, after the company announced positive results from a preclinical trial of its potential treatment of hepatitis C.
Dow's Tumble Is Worst in 2012
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Our experience may provide some useful information for the reform of preclinical experimental class of Periodontology.
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To establish a method to diagnose Anderson fabry preclinically at gene level.
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(This is not quite the same as preclinical, paraclinical, paramedical, nursing, specialties, superficialities etc., which are divisions but without conceptual differences.
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Alzheimer's disease is characterised by a preclinical phase, during which cognitive deficits are seen before diagnosis
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Today, gross anatomy is taught in a preclinical dissection course for second year medical students.
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In preclinical trials, it has been shown to reduce the incidence of diabetes in animals, apparently by down-regulating the immune response.
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The grant will fund two clinical trials, three preclinical research studies, and a training program in gene therapy.
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There is ample evidence of a prolonged preclinical phase in lung cancer.
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She completed her preclinical training at technical colleges before going to Leeds, where she met her husband, Benno Pollak.
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Data from a screening study showed that a screening interval of nine months was too long, and from this it was assumed that bladder cancer has a brief preclinical duration.
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Moreover, we screened for preclinical signs and not for signs of overt lung disease.
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There will be only two major examinations, one after the preclinical phase and the last one after the practical year, but examinations on the individual clinical subjects will be held after each course.
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In future medical courses will comprise six years: two years of preclinical studies, three years of clinical studies, and one year of practical work on the wards.
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Between 1991 and 1995, some students were sent for preclinical training in Australia and South Africa as well as Britain.
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Diseases with long preclinical phases are more likely to be detected by screening.
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Electronic databases will continue to grow in size and cover medicine, nursing, dentistry, veterinary medicine and the preclinical sciences.
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Drug Reports are summaries of drugs in development from preclinical to launched drugs.
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Although the preclinical data have been promising, human studies using vitamin A or retinoids as chemopreventive agents have been largely disappointing.
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The efficacy and safety of some of the new vaccine candidates have been evaluated and proven in human preclinical / clinical trials.
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Improved understanding of this illness during the slow progression from preclinical to moderate disease would aid the development of strategies for primary and secondary prevention.
