How To Use Purine In A Sentence
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Adenosine deaminase is an aminohydrolase that converts adenosine to inosine and is thus involved in the catabolism of purine bases.
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I would like to digress at this point, to describe another use for allopruinol which materialized about 10 years later, because it typifies the kind of chemotherapeutic selectivity which can be achieved with purine analogs as the result of differences in the specificties of parasitic and mammalian enzymes.
Nobel Lecture The Purine Path To Chemotherapy
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The ten Light emanations purines a n d cytosine which is a are necessary to preserve the cor - pyrimidine.
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The next regimen they would try would be a combination of all four drugs: vincristine, amethopterin, mercaptopurine, and prednisone.
The Emperor of All Maladies
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In an attempt to shed light on this matter, we have studied the intrinsic fluorescence properties of the purine and pyrimidine nucleosides dA, dG, dT, and dC in organic solvents in the presence of small amounts of water.
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All these foods contain high levels of purine, which the body metabolises into uric acid - hence gout.
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Scientists have long known that gout develops when joints become fouled with crystals of uric acid, which is a natural digestion product of purine.
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Side effects included pancreatitis and shingles that resulted in discontinuation of 5-acetylsalicylic acid, leukopenia corrected by withholding 6-mercaptopurine and self-resolved hepatitis.
IBD clinical studies: drug comparisons
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Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger.
Recent Publications
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Other studies have demonstrated that azathioprine, which is in the thiopurine class, can increase the photosensitization of human skin.
Undefined
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Purines protected by Jun are denoted by asterisks whose size correlates with the degree of protection.
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He also studied the orientation of purines and pyrimidines in tobacco mosaic virus and in nucleic acids, by measuring the ultraviolet dichroism of oriented specimens, and he studied, with the visible-light polarizing microscope, the arrangement of virus particles in crystals of TMV and measured dry mass in cells with interference microscopes.
Maurice Wilkins - Biography
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Uric acid is a byproduct of the metabolism of purine, a protein found particularly in red meat and offal, game, seafood and alcoholic drinks (particularly beer, lager, port and red wine).
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Glutamine is an energy source for enterocytes of the small intestine, helps form nicotinamide for energy transfers and glucosamine for connective tissue, and contributes to purine and pyrimidine nucleotides.
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The composite elements are arranged in a bicyclic fashion which is a derivative of a purine ring system.
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It appears that the purine metabolic system in humans has found a way to avoid the overproduction of uric acid by downregulating the Xor gene expression, the product converting hypoxanthine to xanthine and further xanthine to uric acid.
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The major enzymological studies underway in the field of biochemistry prior to 1950 unfortunately were focused on carbon metabolism, not on amino acid, vitamin, purine, or pyrimidine biosynthesis.
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A new synthetic method of 2-Amino-6-Chloropurine using phosphorus pentachloride as halogenating agent is introduced. The halogenating agent and temperature influential factors are discussed.
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The purines adenine and guanine are constituents of DNA.
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The purine and pyrimidine bases in cells are linked to carbohydrate and in this form are termed, nucleosides.
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With the latter therapy, once patients are weaned from steroids, the purine antimetabolite is continued for an indefinite period while the physician monitors white blood cell count and liver enzymes.
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Purine salvage pathway allows interconversion of bases, nucleosides and nucleotides.
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Most can handle standard doses of the drug mercaptopurine.
A Revolution In Medicine
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Causes and effects The structure of thalidomide is similar to that of the DNA purine bases adenine and guanine.
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Dietary purine intake may provide a significant source of uric acid.
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The next regimen they would try would be a combination of all four drugs: vincristine, amethopterin, mercaptopurine, and prednisone.
The Emperor of All Maladies
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This view was reinforced by the elucidation of Z DNA and Z RNA structures, where the syn purines are mostly guanines.
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Weight reduction, purine restriction, and cessation of ethanol use should be accomplished.
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Both purine and pyrimidine bases present similar PI yields at 266 nm.
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This involves formation of a hybrid triplex by two PNA strands and a homopurine strand of dsDNA whereas the other DNA strand is displaced from the double helix.
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For this reason, individuals with kidney problems or gout may want to limit or avoid intake of purine-containing foods such as crimini mushrooms.
The World's Healthiest Foods
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The derivatives of purine are called adenine and guanine, and the derivatives of pyrimidine are called thymine, cytosine and uracil.
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The derivatives of purine are called adenine and guanine, and the derivatives of pyrimidine are called thymine, cytosine and uracil.
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Two of these, adenylate kinase and purine nucleoside phosphorylase, contain potential critical building blocks.
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Purines and pyrimidines are considered as complex molecules themselves because they are never synthesized as such in vivo.
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However, studies with a 6-mercaptopurine-resistant strain of L. casei revealed the 6-MP was unable to utilize hypoxanthine for growth (29).
Nobel Lecture The Purine Path To Chemotherapy
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Six weeks later, he gave the boy four courses of high-dose methotrexate, daily mercaptopurine, and four triple-drug treatments into the spinal fluid.
Curing Cancer
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The patients 'average age at the initiation of treatment with 6-mercaptopurine and azathioprine was 13.8 years.
IBD clinical studies: drug comparisons
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Depending on the legume species, fixed nitrogen is exported as either amides (glutamine and asparagine) or ureides (allantoin and allantoic acid), which are initially derived from the oxidative breakdown of purines.
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Learn about the research that led to the use of the antimetabolite drugs 6-mercaptopurine
The Spark of Yahoo!
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In comparison with the deamination of cytosine to uracil, the deamination of DNA purines is a minor reaction.
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A nitrogenous molecule, either a PYRIMIDINE or a PURINE, that combines with a pentose sugar and phosphoric acid to form a nucleotide, the fundamental unit of nucleic acids.
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Side effects included pancreatitis and shingles that resulted in discontinuation of 5-acetylsalicylic acid, leukopenia corrected by withholding 6-mercaptopurine and self-resolved hepatitis.
IBD clinical studies: drug comparisons
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Adenosine deaminase is an aminohydrolase that converts adenosine to inosine and is thus involved in the catabolism of purine bases.
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All the Arbroath smokies, the oak-smoked kippers, the tinned pilchards, the wild salmon leaping up the glens -- all that purine.
BLOOD IS DIRT
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This is the enzyme responsible for converting adenosine to inosine in the catabolism of the purines.
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Determination of rumen microbial - nitrogen of sheep using urinary excretion of purine derivatives was studied.
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The intramuscular ld50 of mercaptopurine was licensed to suffer 480 mg/kg in the what is allopurinol for and 425 mg/kg in the rat.
Wii-volution
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We deduced that adenine and 2,6-diaminopurine must be anabolized by the same enzyme, and that the product of diaminopurine anabolism interfered with purine interconversion (17).
Nobel Lecture The Purine Path To Chemotherapy
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The nucleotides found in cells are derivatives of the heterocyclic highly basic, compounds, purine and pyrimidine.
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Purine salvage pathway allows interconversion of bases, nucleosides and nucleotides.
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They prevented rabbits from producing antibody against human serum albumin by treating them for two weeks with the antimetabolite, 6-Mercaptopurine.
Joseph E. Murray - Nobel Lecture
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Besides a low purine diet, preventive medicines such as allopurinol, febuxostat, and probenecid can be used to prevent recurrences.
The Daily Times News Headlines
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The chemical and biological effects of UV radiation on purine and pyrimidine nucleosides and nucleotides have been the subject of many studies.
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The composite elements are arranged in a bicyclic fashion which is a derivative of a purine ring system.
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Turkey contains purines, substances that the body converts to uric acid.
Times, Sunday Times
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Tisupurine is more water-soluble than mercaptopurine (6-MP). Easily release 6-MP under acidic condition or the existing of sulfhydryl compounds, has selectivity to tumor tissue.
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In 1902 Emil Fischer, then in Berlin, was given the prize for "his work on sugar and purine syntheses".
The Nobel Prize in Chemistry: The Development of Modern Chemistry
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The enzymes guanase and xanthine oxidase were useful in our laboratory to examine the purines as substrates or inhibitors of these enzymes
Nobel Lecture The Purine Path To Chemotherapy
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The synthesis of nucleotides from the purine bases and purine nucleosides takes place in a series of steps known as the salvage pathways.
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Adenosine deaminase is an enzyme of purine metabolism which catalyses adenosine into inosine and is found in most human tissues particularly in the lymphoid tissues.
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Would the arabinoside of 2,6-diaminopurine be equally active?
Nobel Lecture The Purine Path To Chemotherapy
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Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors.
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Furthermore, although Powner and colleagues 'synthetic sequence yields the pyrimidine ribonucleotides, it cannot explain how purine ribonucleotides (which incorporate guanine and adenine) might have formed.
Convincing Evidence for God
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A nucleotide is a combination of a ribose or deoxyribose sugar, a purine or pyrimidine base, and a phosphate group.
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The median time to discontinuation of corticosteroid after initiation of 6-mercaptopurine and azathioprine therapy was 8.4 months.
IBD clinical studies: drug comparisons
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They form phosphorus-containing organic substances which, together with a form of phosphoric acid, usually contain purine bodies, pyrimidine bodies and a form of sugar or related substance.
Nobel Prize in Physiology or Medicine 1910 - Presentation Speech
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We found that diaminopurine arabinoside (ara-DAP) was deaminated to guanine arabinoside in mice and that the guanine derivative
Nobel Lecture The Purine Path To Chemotherapy
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Oxidized bases (both pyrimidines and purines) and misincorporated uracil, were similar for fresh and frozen lymphocytes.
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One cancer of particular concern is a rare type of lymphoma called hepatosplenic T-cell lymphoma that has been reported mostly in adolescent or young adult male patients who were also on immunosuppressant medications known as thiopurines, making the role of drugs like Remicade unclear.
FDA Panel Backs Additional Use of J&J's Remicade
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Objective : To investigate the effect of morphine on purine nucleotide catabolism and the mechanism.
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We found that diaminopurine arabinoside (ara-DAP) was deaminated to guanine arabinoside in mice and that the guanine derivative
Nobel Lecture The Purine Path To Chemotherapy
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The derivatives of purine are called adenine and guanine, and the derivatives of pyrimidine are called thymine, cytosine and uracil.
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Later it was found that homopurine strands can also specifically form a DNA triplex in which the AT base pair is contacted by an A and the GC base pair by a G.
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Indeed, all the genes encoding enzymes required for de novo AMP biosynthesis are repressed at the transcriptional level by the presence of extracellular purines (adenine or hypoxanthine).
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Clofarabine, a type of drug called a purine nucleoside antimetabolite, works by blocking the production and repair of DNA, the building blocks of genes.
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Dietary purine intake may provide a significant source of uric acid.
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Two of the named four bodies, adenine and guanine, belong to a group of chemical compounds which today are usually included under the name of alloxan derivatives or purine derivatives.
Albrecht Kossel - Nobel Lecture
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She thought she would add various chemical side chains to each of the six carbon atoms, producing dozens of new variants of purine.
The Emperor of All Maladies
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Furthermore, although Powner and colleagues 'synthetic sequence yields the pyrimidine ribonucleotides, it cannot explain how purine ribonucleotides (which incorporate guanine and adenine) might have formed.
Convincing Evidence for God
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Two other ways of recoding the data were cited: eliminating third codon positions and recoding nucleotides as purines and pyrimidines.
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Indeed, guk1 and hpt1 mutants share several phenotypes (adenine derepression, purine excretion, and 8-azaguanine resistance).
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I started reading about Alzheimer's and tried to familiarize myself with the research, and at the same time when I was in the -- I was reading in the medical library one day, and I read this article about something called purine derivatives.
Eva Vertes looks to the future of medicine
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When a 12-year-old boy from Illinois with ALL arrived at St. Jude in 2001, Pui administered everything but the kitchen sink: the drugs prednisone, vincristine, daunorubicin, and asparaginase, followed by cyclophosphamide, cytarabine, and mercaptopurine.
Curing Cancer
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Moreover, diaminopurine riboside was a poorer substrate for adenosine deaminase than was adenosine.
Nobel Lecture The Purine Path To Chemotherapy
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Take the anticancer drug Purinethol: A variant in agene called TPMT causes one in 300 childhood leukemia patients to suffer life-threatening side effects from the med.
15th Anniversary: DNA-Customized Medicine Still Stuck in the Pipeline
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When a 12-year-old boy from Illinois with ALL arrived at St. Jude in 2001, Pui administered everything but the kitchen sink: the drugs prednisone, vincristine, daunorubicin, and asparaginase, followed by cyclophosphamide, cytarabine, and mercaptopurine.
Curing Cancer
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They were then analyzed for the development of side effects, the indication to use 6-mercaptopurine and azathioprine and the ability to discontinue corticosteroid use in those patients taking 5-acetylsalicylic acid products who were corticosteroid-dependent or whose disease was refractory to treatment.
IBD clinical studies: drug comparisons
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The purines adenine and guanine are constituents of DNA.
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Previous work on Drosophila de novo purine synthesis genes showed that 4 mg/ml RNA supplementation can rescue the phenotype of auxotrophic mutants fed a defined medium.
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Our data confirm that the polypurine TFO binds in an antiparallel orientation with respect to the polypurine DNA strand and that triplex formation requires Mg 2 + ions whereas it is inhibited by K + ions.
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The data support the safety of 6-mercaptopurine and azathioprine use in the treatment of pediatric patients with ulcerative colitis; side effects were minimal and reversible.
IBD clinical studies: drug comparisons
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The liposomal ld50 of mercaptopurine was compared to fold 480 mg/kg in the and 425 mg/kg in the rat.
Wii-volution
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The result was azathioprine (1957) which replaced mercaptopurine as an inhibitor of the immune response.
Physiology or Medicine 1988 - Press Release
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Conversely, the reaction of purine and pyrimidine nucleobases with alkylating and oxidizing agents generally results in site-specific cleavage.
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The nitrogenous bases belong to two classes of molecules - purines and pyrimidines.
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Uric acid levels are elevated when injesting too much purine, which is found in red meats, legumes, beer, and vegetables such as asparagus and
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Dietary purine intake may provide a significant source of uric acid.
