How To Use Sickle cell In A Sentence
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Current areas of investigation include neurohumoral, cellular and molecular mechanisms regulating airway contractility, airway smooth muscle growth and cell surface receptor expression; regulation of postnatal development and growth of the lung; developmental effects of pulmonary inflammation and oxidative lung injury on airway and pulmonary vascular reactivity; biochemical and molecular regulation of membrane ion channels in cystic fibrosis; maturational changes in chest wall and airway function; pulmonary manifestations of sickle cell disease; the physiological basis of ventilator dependence in children with chronic respiratory insufficiency; and developmental aspects of respiratory mechanics and ventilatory control.
Fellowship Program in Pulmonary Medicine
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A clear example of a mutation altering development is the inherited genetic defect, sickle cell anaemia.
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Sickle cell anemia is an inherited blood disease that can cause bouts of pain, damage to vital organs and, sometimes, death in childhood.
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In so-called recessive disorders, such as sickle cell disease, your child needs to inherit two bad copies of the gene - one from each parent - to develop the disease.
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Sickle cell anemia is overrepresented among the AA population here.
The Volokh Conspiracy » 1. Science, Faith, and Not Ruling Out Possibilities
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Chronic and acute problems associated with sickle cell anaemia.
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Diagnosis of the clinically severe forms of sickle cell disease is not difficult, providing awareness of the disease is high.
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A clear example of a mutation altering development is the inherited genetic defect, sickle cell anaemia.
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An example of overdominance is the allele in black Africans that confers resistance to malaria when present in one chromosome (heterozygous), but causes sickle cell anemia when present in both (homozygous).
"The more we play God or try to improve on Mother Nature, the more damage we are doing with all kinds of experiments that... turn into nightmares."
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In recent years, sickle cell disease and thalassaemia, both conditions largely confined to ethnic minorities, have gained increasing recognition by the white dominated health services in the United Kingdom.
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Sickle cell crises are extremely rare but affected individuals should be warned of the potential dangers of severe hypothermia or hypoxia.
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Detection of high blood pressure in the lungs may also account for the unexplained or mistakenly explained sudden deaths in adult patients with sickle cell disease.
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These conditions include sickle cell anemia, beta thalassemia, phenylketonuria PKU, hypothyroidism,8 and galactosemia.
Pregnancy, Childbirth, and the Newborn
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Sickle cell anemia is caused by the replacement of glutamate by valine at the sixth position of the [beta] globin chain.
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At baseline, levels of circulating leucocytes and vascular cell adhesion molecules were elevated in the sickle cell mice.
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Infections are the leading cause of death in sickle cell disease.
Diagnosing and treating sickle cell disease
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Some well-understood examples of these sorts of mutations include the single base pair changes that lead to cystic fibrosis, sickle cell anemia or other, rarer hereditary diseases like familial dysautonomia or acid maltase disease (a.k.a. Glycogen storage disease type II or Pompe disease, as was featured in recent Harrison Ford flick Extraordinary Measures).
Dr. Elaine Schattner: An Educated Medical Consumer: On Personal DNA Testing
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In-utero hematopoietic stem cell transplantations are a promising approach for the treatment of selected congenital immunodeficiency disorders (i.e. severe combined immunodeficiencies, chronic granulomatous disease, hyperIgM syndrome and others) and hemoglobinopathies (i.e. sickle cell disease and thalassemia).
In Utero Stem Cell Transplantation
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if you could prevent the switch from happening, or reverse it, and let people with sickle cell disease use fetal hemoglobin for life, that should reduce symptoms.
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Thus, consistent with previous findings, these dense cells are likely to contribute to poor rheology of sickle cell blood at all O2 saturations.
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The blood dyscrasias that most commonly lead to leg ulceration are sickle cell disease, thalassaemia, thrombocythaemia, and polycythaemia rubra vera.
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I mean, there's a reality of -- I mean, hey, we don't even hear the word sickle cell anymore now, do we?
CNN Transcript Jul 9, 2007
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Prior to her current pregnancy, this patient had been admitted 3 times during adolescence for sickle cell crises and had documented retinopathy.
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Sickle cell erythrocytes have decreased oxygen affinity and increased unsaturated hemoglobin in the arterial blood.
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A A haemoglobinopathy; for example, sickle cell anaemia or thalassaemia
Latest headlines from BMJ
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People with sickle cell anaemia and thalassaemia are known to have red cells with defects in their outer membranes.
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Chronic and acute problems associated with sickle cell anaemia.
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The inability to maximally concentrate urine is the most common renal abnormality in sickle cell disease.
Diagnosing and treating sickle cell disease
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Chronic and acute problems associated with sickle cell anaemia.
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Social workers at the Sickle Cell Center provide a wide range of services related to psychosocial needs in coping with chronic illness as well as navigation through hospital and insurance systems.
Sickle Cell Clinical Program at The Children's
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In addition to your child's primary care doctor, your child should receive regular care from a hematologist (a blood specialist) or a sickle cell clinic.
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Members of the stroke team work closely with the sickle cell team to provide comprehensive care to our sickle cell patients who are at risk or have experienced cerebrovascular complications, including stroke.
Sickle Cell Clinical Program at The Children's
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Sickle cell anemia is caused by a mutation from a glutamate to a valine in the beta chain of the hemoglobin molecule.
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The most effective way of organising specialist care is through sickle cell centres, which can offer both clinical and psychological support.
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In sickle cell disease, the amino acid valine is substituted for glutamic acid in the beta-hemoglobin chain of hemoglobin.
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At the time of aplasia, the child with sickle cell disease is highly contagious.
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Some disorders or conditions, such as albinism and sickle cell disease, are passed on from the parents to the children.
Chapter 7
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Current areas of investigation include neurohumoral, cellular and molecular mechanisms regulating airway contractility, airway smooth muscle growth and cell surface receptor expression; regulation of postnatal development and growth of the lung; developmental effects of pulmonary inflammation and oxidative lung injury on airway and pulmonary vascular reactivity; biochemical and molecular regulation of membrane ion channels in cystic fibrosis; maturational changes in chest wall and airway function; pulmonary manifestations of sickle cell disease; the physiological basis of ventilator dependence in children with chronic respiratory insufficiency; and developmental aspects of respiratory mechanics and ventilatory control.
Fellowship Program in Pulmonary Medicine
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In Britain one in ten black people carry the sickle cell gene.
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In this research, arginine is given in pill form to determine if it can reduce or prevent symptoms in people with sickle cell disease.
Sickle cell disease research at The Children's Hospital
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A randomized, multicenter, phase II study to evaluate the safety and efficacy of oral ICL670 (deferasirox) 20 mg/kg/day relative to subcutaneous deferoxamine in sickle cell disease patients with iron overload from repeated blood transfusions
Sickle cell disease research at The Children's Hospital
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We assumed that the same mechanism that is involved in differentiation and maturation of the reticulocyte is also involved in the removal of "naturally occurring" mutant abnormal hemoglobins that are synthesized in different hemoglobinopathies, such as thalassemias and sickle cell anemia, and also in the destruction of the amino acid analogs
Aaron Ciechanover - Autobiography
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These students work in laboratories in which research in sickle cell disease is performed.
Sickle cell disease research at The Children's Hospital
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This investigation was a retrospective, histochemical, morphometric study of blood vessels in hematopoietic bone marrow in cases of sickle cell hemoglobinopathy and in age group-matched normal control subjects.
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Bone marrow transplantation may be considered in some cases of sickle cell anemia, thalassemia, and aplastic anemia.
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Sickle cell crises are extremely rare but affected individuals should be warned of the potential dangers of severe hypothermia or hypoxia.
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Diseases as disparate as scleroderma, cystic fibrosis, kyphoscoliosis, sleep apnea, and sickle cell disease were found to have shared consequences in the pulmonary circulation.
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Plasmapheresis has been available for decades and is most commonly used in treatment of systemic lupus erythematosus, myasthenia gravis, sickle cell crisis, and oncological disorders such as lymphoma and multiple myeloma.
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Haemoglobin electrophoresis showed sickle cell trait.
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An example is sickle cell disease, where the red cells become rigid and deformed and break down more readily, leading to anaemia.
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The deaths from malaria among AA persons were balanced out by the increased survival among AS persons, which is why sickle cell disease remained in malarial areas.
An Evolutionary Model of Depression, Bryan Caplan | EconLog | Library of Economics and Liberty
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The most effective way of organising specialist care is through sickle cell centres, which can offer both clinical and psychological support.
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Important health maintenance measures in sickle cell disease include:
Diagnosing and treating sickle cell disease
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At baseline, levels of circulating leucocytes and vascular cell adhesion molecules were elevated in the sickle cell mice.
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Sickle cell disease is a blood disease that children inherit from their parents.
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Other significant conditions were aspiration of vomitus and sickle cell disorder.
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* Enjoyed this from Boing Boing: lecture from Stanford professor Robert Sapolsky on evolution, religion, schizophrenia and the schizotypal personality, arguing by analogy to sickle cell that schizophrenia is the hypertrophic result of genes that in isolation reward their holder with feverous religious certainty.
Brand New Day Monday « Gerry Canavan
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Normal red blood cells are round and pliable, but in persons with sickle cell anemia these cells become firm and inflexible.
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This project is designed to establish a comprehensive understanding of the structures, factors and mechanisms that affect the stability of human beta-globin mRNA. This information promises to be helpful in designing therapies for sickle cell disease.
Sickle cell disease research at The Children's Hospital
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A hematologist can assist in the often difficult task of determining the exact type of sickle cell disease, especially in the presence of rarer hemoglobin variants.
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Chronic transfusion for stroke prevention is now the standard of care for sickle cell patients at high risk of stroke.
Sickle cell disease research at The Children's Hospital
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Commemorating a key event in sickle cell disease history
Sickle Cell First Global Congress in Ghana
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Nutrition supplementation studies in sickle cell disease
Sickle cell disease research at The Children's Hospital
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People with sickle cell anaemia and thalassaemia are known to have red cells with defects in their outer membranes.
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People with sickle cell trait don't have sickle cell disease or exhibit any signs of the disorder, but they can pass the gene for the disease to their children.
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Bone marrow transplantation may be considered in some cases of sickle cell anemia, thalassemia, and aplastic anemia.
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World leaders in sickle cell research will present new research findings at the meeting.
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This may be the first symptom of sickle cell disease in babies, who also may develop a fever.
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Some well-understood examples of these sorts of mutations include the single base pair changes that lead to cystic fibrosis, sickle cell anemia or other, rarer hereditary diseases like familial dysautonomia or acid maltase disease (a.k.a. Glycogen storage disease type II or Pompe disease, as was featured in recent Harrison Ford flick Extraordinary Measures).
Dr. Elaine Schattner: An Educated Medical Consumer: On Personal DNA Testing
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Ionic contrast media, when injected intravenously or intra-arterially, may promote sickling in individuals who are homozygous for sickle cell disease.
Patient Preference For Omnipaque (Iohexol) Highlighted In First Head-To-Head Taste Test of Oral Contrast Agents - Yahoo! Finance
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A one-year open label, non-comparative extension to a randomized, multicenter, phase II study to evaluate the safety, tolerability, pharmacokinetics and the effects on liver iron concentration of repeated doses of 5-30 mg/kg/day of ICL670 (deferasirox) relative to deferoxamine in sickle cell disease patients with transfusional hemosiderosis
Sickle cell disease research at The Children's Hospital
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How does assist patients with sickle cell disease?
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(such as angulation, cavernosal fibrosis or Peyronie's disease), or in patients who have conditions which may predispose them to Priapism (such as sickle cell anemia, multiple myeloma, or leukemia).
Xml's Blinklist.com
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The blood dyscrasias that most commonly lead to leg ulceration are sickle cell disease, thalassaemia, thrombocythaemia, and polycythaemia rubra vera.
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However, her medical records indicate that she has bronchitis, TB, bilharzia, malaria, juvenile rheumatoid arthritis and multiple coughs and colds, all due to sickle cell.
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One patient had sickle cell anemia and showed sickled red blood cells in the dilated sinusoids.
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Dr Allison Streetly, national dir, NHS sickle cell and thalassaemia screening programme, for serv healthcare.
New Year honours list: Order of the British Empire, Officer
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In recent years, sickle cell disease and thalassaemia, both conditions largely confined to ethnic minorities, have gained increasing recognition by the white dominated health services in the United Kingdom.
