How To Use Sporozoite In A Sentence
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Pre-clinical data from earlier studies indicated significantly enhanced immune responses against the malaria parasite (circumsporozoite stage of the Plasmodium falciparum) when Crucell's AdVac� technology and GSK's RTS, S/AS technology are used in combination, versus either component alone.
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Pre-clinical data from earlier studies indicated significantly enhanced immune responses against the malaria parasite (circumsporozoite stage of the Plasmodium falciparum) when Crucell's Adenovirus (AdVac®) technology and GSK's RTS, S/AS technology are used in combination, versus either component alone.
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Meiotic division then gives rise to haploid cells that develop into infective sporozoites, which migrate to the mosquito salivary glands and infect humans during mosquito blood-feeding.
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Plasmodium falciparum concurs, stating, "This is a very exciting opportunity to make significant strides that will facilitate translation from the laboratory to clinical studies of a vialed, genetically attenuated, sporozoite Pipeline status of allergy drugs, new developments and disease specific projects
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In order to verify this methodology, we probe here the effect of EGCG in combination with the adjuvant digitonin as a membrane permeabilising agent on Effect of EGCG on Plasmodium Sporozoite Survival, Motility, and Liver Cell Infection
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Using Crucell's AdVac® technology with two different adenovirus vectors - Ad35 and Ad26 - as delivery mechanisms, this approach seeks to elicit a protective immune response obtained from delivering the circumsporozoite protein (CSP).
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How many sporozoites are produced by each oocyst, Jehu?
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The sporozoites migrate to the salivary glands and are inoculated into a new vertebrate host when the mosquito feeds.
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The vaccine, which generates an immune response to the parasite's circumsporozoite protein, is far from perfect.
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The sporozoites, injected by the infected female Anopheles mosquito, are carried to the liver, where they undergo asexual forms known as exoerythrocytic schizogony to form merozoites.
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Sporozoites, the product of sporogony, migrate to the salivary glands and are injected into the bloodstream when a mosquito bites a person.
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Plasmodium berghei (strain NK65) sporozoites constitutively expressing cytoplasmic green fluorescent protein (GFP) under the control of the stage specific circumsporozoite (CS) promoter were produced in
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Fujioka H, Gantt S, Nussenzweig R, Nussenzweig V, et al. (2002) Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology.
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The sexual phase of the Plasmodium life cycle is completed with the fertilization of a macrogamete by a flagellar microgamete, and the subsequent generation of sporozoites.
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The protein they chose, called CSP, covers the surface of the malaria sporozoite and is thought to be the main reason that this form of the parasite stimulates the immune system so effectively.
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Infection by sporozoites reduces the fecundity of mosquitoes.
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The goal of this study was to compare the effects of malaria oocysts and sporozoites on the two mechanisms that could affect the mosquito's biting rate: motivation and efficiency.
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Tissue damage to the host's liver, kidney, spleen, lungs, or other organs can occur when the vector injects sporozoites that enter host cells to develop into meronts.
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The sexual phase of the Plasmodium life cycle is completed with the fertilization of a macrogamete by a flagellar microgamete, and the subsequent generation of sporozoites.
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The circumsporozoite protein CSP has been recognized as a potential target in the development of vaccines focused on the earlier stages of malaria infection.
The PATH Malaria Vaccine Initiative, Merck and NYU Langone Medical Center Collaborate to Research Potential Malaria Vaccine - Yahoo! Finance
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Oocytes ingested from contaminated soil or other sources excyst in the duodenum, and released sporozoites invade the intestine.
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Fujioka H, Gantt S, Nussenzweig R, Nussenzweig V, et al. (2002) Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology.
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However, protection was lost upon re-challenge at 6 months with 250 infectious sporozoites, implying that sterile protective immunity induced by the transferred CD11c
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Dr. Robert Sauerwein of the Radboud University Nijmegen Medical Centre, whose laboratory in collaboration with Sanaria has generated several genetically attenuated strains of Plasmodium falciparum concurs, stating, "This is a very exciting opportunity to make significant strides that will facilitate translation from the laboratory to clinical studies of a vialed, genetically attenuated, sporozoite vaccine inoculated by needle and syringe.
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Maturation of the oocysts leads to sporozoite release into the hemocoel.
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An. stephensi blood meal, (H) an infected gut 8 days post-feed, (I) 10 day oocyst, (J) infected salivary gland dissected 18 days post-feed, (K) salivary gland sporozoite.
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The sporozoites released from the oocyst reproduce asexually within cells, producing merozoites that burst from those cells, each to infect a new cell.
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This paper summarized the research advance in the live attenuated vaccine, sporozoite vaccine and DNA vaccine.
