NOUN
- a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
How To Use suppressor gene In A Sentence
- These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.
- Neurofibromatosis type 1 is a common autosomal dominant disorder with a high rate of penetrance. It is caused by the mutation of the tumor suppressor gene NF1, which encodes neurofibromin.
- In contrast, the chapter on cancer cytogenetics essentially assumes that the reader possesses an understanding of the concepts of oncogenes and tumor suppressor genes and their applications in cytogenetics.
- Scientists believe the suppressor gene can be inactivated by tobacco, viruses, pollution or diet.
- The tentative map location of the suppressor gene or of the nearby Tn10dTc element was determined using the Mud-P22 lysogen collection of BENSON and GOLDMAN 1992.
- P 53 gene is found in human tumors so far the most relevant tumor suppressor gene.
- However, they point out that several genes, including potential oncogenes and tumor suppressor genes, failed to revert to never-smoker levels even after 30 years of cessation.
- Tumor suppressor genes play a key role in the regulation of cell growth.
- The genes found to undergo genetic alterations in cancer have been placed into two categories: oncogenes and tumor suppressor genes.
- Tumor suppressor genes are located on autosomal chromosomes.
