NOUN
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a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape
the centromere is difficult to sequence
How To Use kinetochore In A Sentence
- We now believe that proteins in a structure called the kinetochore are among the most sensitive to degradation or mutation. Science Blog - Science news straight from the source
- This force increases the efficiency with which chromosomes make bipolar spindle attachments and regulates kinetochore activities necessary for chromosome oscillation, but is not essential for chromosome congression. Sub-cellular ID Spin - The Panda's Thumb
- Chromosome loss may be the result of either non-attachment of the chromosome kinetochore to the spindle microtubules or chromosome lagging at anaphase and gives rise to a micronucleus.
- Kinetochore microtubule bundles link sister chromosomes to the poles.
- The initial study of centromere coupling reported that in chromosome spreads exhibiting centromere coupling, Zip1 foci and kinetochore pairs occur in approximately equal numbers (about sixteen) and exhibit a high level of co-localization PLoS ONE Alerts: New Articles
- A second checkpoint pathway, the spindle checkpoint, operates at a similar point in meiosis, preventing progression into anaphase if the spindle apparatus fails to connect appropriately with kinetochores.
- Second, the centromere is the focus for the formation of the kinetochore, where microtubules connect to the chromosomes during anaphase in mitosis and meiosis.
- Spindle fibers, composed of microtubules, have attached to the sister pairs of chromosomes at their point of attachment the kinetochore, or centromere. THE HIDDEN FACE OF GOD
- The spindle assembly checkpoint pathway is necessary for high-fidelity chromosome transmission in cells in which the spindle or kinetochores are compromised in some way.
- Kinetochore proteins bind to a microtubule spindle to keep chromosomes segregated during cell division.